Stay with Siemens if your team depends on PADS-specific libraries, HyperLynx integration, or corporate standardization. Moving up to PADS Professional keeps vendor continuity and the least retraining.
Altium Designer is the default answer when teams want a modern commercial mainstream tool with a large hiring pool and published licensing. Budget for library rebuild time; automated translators get you part of the way and a cleanup pass finishes the job.
KiCad is the answer when license cost or file ownership drives the decision. Projects are open files on your disk, the toolchain is scriptable, and the community is enormous. The trade is that library and process discipline lands on your team.
ProtoFlow is not a fifth layout tool in this fight; it is the free AI layer you can add today. New designs start as a plain-English brief, become a real schematic with distributor parts, pass ERC and DRC, and land as a native KiCad project, which keeps every downstream option above open.