Full replacement on a budget: KiCad. It is free, open source, runs on Mac, Windows, and Linux, and its differential-pair routing, tuning tools, and custom design-rule system now cover mainstream high-speed work. The trade is manual effort and a library workflow you own yourself.
Full replacement with commercial support: Altium Designer. It is the most common landing spot for teams leaving Cadence tools, with published licensing, a large community, and strong layout and data-management tooling.
Early-stage speed without replacing anything: ProtoFlow. Draft the schematic from a plain-English description, pull real distributor parts, run ERC and DRC, and export a native KiCad project. Teams that keep Allegro downstream use it to compress the concept-to-reviewed-schematic stage, the part of the flow where Allegro is slowest to iterate.