Three things, mostly. First, constraint-driven design that scales: rule sets, differential pairs, length matching, and impedance handling that stay manageable on a large high-speed board. Second, team data management, where Altium 365 handles library governance, version control, release management, and review in a way that does not require you to invent a process. Third, integrated supply-chain data, with component availability and pricing surfaced inside the design tool rather than in a browser tab.
If you are a team of eight shipping regulated products with a shared component library and a release process, those are not luxuries. If you are one person designing a sensor board, you will pay for all three and use approximately none of them.